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Medications can significantly affect an individual’s acclimatization to heat and may increase the risk of heat illness. Certain medications can impact the body's ability to regulate temperature or may alter fluid balance, increasing susceptibility to heat stress. For instance, some medications can cause dehydration as a side effect, while others may impair sweating or blood circulation, which are crucial functions for regulating body temperature during heat exposure.

While factors like the time of day, type of work, and clothing can influence how an individual experiences heat, they do not directly change the physiological processes involved in acclimatization in the same way that certain medications can. Proper acclimatization involves physiological adjustments that typically occur over time with exposure to heat, but medications can hinder or disrupt this process, making it a critical factor in assessing risk for heat-related illnesses.